What is
Plaque Psoriasis ?

Plaque psoriasis is the most common form of psoriasis, a chronic autoimmune disease that causes raised, scaly, itchy patches of skin (called plaques) to appear on the body, typically on areas like the elbows, knees, scalp, and lower back; these plaques can be red and covered with silvery-white scales, and their appearance may vary depending on skin color.

WHAT CAUSES PLAQUE PSORIASIS?
What is
TYK2 in Plaque Psoriasis ?
TYK2 (Tyrosine Kinase 2) is an enzyme that belongs to the Janus kinase (JAK) family, which play a crucial role in signaling pathways involved in inflammation.
 
  • In Plaque Psoriasis, TYK2 is involved in the signaling pathways of cytokines like IL-23, IL-12, and type I interferons.
  • These cytokines are major drivers of the inflammation that causes Plaque Psoriasis 
How common is
Plaque Psoriasis?

Plaque psoriasis is the most common type of psoriasis. About 80% to 90% of people with psoriasis have plaque psoriasis.

Symptoms of Moderate to severe
plaque psoriasis
Symptoms may include:
  • Red patches of skin covered with thick, silvery scales
  • Small scaling spots
  • Dry, cracked skin that may bleed or itch
  • Itching, burning, skin tightness, or stinging
How CRAVACIN Works ?

Within our immune system there is a molecule known as TYK2, which plays a key role in passing on signals in psoriasis.
With plaque psoriasis, the immune system can become “overactive” and create inflammation, ultimately sending signals that cause skin cells to grow too fast.
CRAVACIN helps to decrease those signals by selectively targeting and blocking TYK2.